Opioid and Cocaine Treatment Research Study
Join a University of Pennsylvania research program evaluating the medication Cariprazine, and examining its effects on drug use
Research Conducted in Philadelphia, PA
Compensation
Provided
Taking prescription Suboxone, Zubsolv, or Bunavail
cocaine and opioid use disorders
18 - 65 Years Old
Fast Facts
Study Background
UPenn is testing an investigational medication for the treatment of Opioid and Cocaine Use Disorder in a highly confidential study.

The purpose of our research study is to see whether taking the medication Cariprazine affects drug use in people struggling with opioid and cocaine use.

Researchers also hope to understand whether certain mental processes (such as inhibition, memory, decision-making, reward, pain sensitivity, etc.) can predict drug use and whether treatment with Cariprazine impacts this.
Additional Information
Why is this study being done?
The purpose of this research study is to see whether taking the medication Cariprazine affects drug use in people with opioid and cocaine use disorder. We'd also like to understand whether certain mental processes (inhibition, memory, decision-making, reward, pain sensitivity, etc.) can predict drug use and whether treatment with Cariprazine impacts these processes.
Is this study for me?
You may qualify for this study if you meet the following criteria.

Key Criteria:
  • You have cocaine and/or opioid use disorders
  • You are taking prescription buprenorphine-naloxone
  • You are deemed eligible after completing a screening process to assess your physical and mental health
What will happen if I participate in the study?
if you choose to participate, you will be randomly assigned to receive Cariprazine or a placebo for 8 weeks while coming into our offices for visits two times per week.

During these visits, we will monitor drug use. You will receive medication and respond to research surveys. We will also measure performance on various behavioral and computerized tasks.

During some tasks, we will monitor your brain activity using a noninvasive neuroimaging technique called functional near-infrared spectroscopy (fNIRS). There is also an option fMRI for those who qualify
Will I be paid for being in this research study?
Participants will be compensated for each study visit completed, with each visit ranging from $25 to $100.
Will it cost me anything to participate in this study?
There will be no charge to you for participating in this research program.