PTSD Treatment Research Study
Have you experienced a traumatic event that significantly affects your everyday life?
Participate in a compensated PTSD treatment study conducted by researchers at NYU Langone Health.
Located in the Greater NYC Area
Compensation Provided
Experienced a traumatic event that significantly affects your life currently
18 - 45 Years Old
Fast Facts
Using Birth Control
Study Background
Roughly 10% of the US adult population lives with symptoms of PTSD and the prevalence rates for women are significantly higher than for men, with an estimated 4% of the women in the United States reporting PTSD symptoms. This condition can lead to people living their life with constant nightmares, trouble engaging in social activities and hamper relationships with relatives and friends.

NYU researchers are studying a new treatment that could help reduce symptoms of PTSD. This in-person compensated research study may be available to you. Find out if you are eligible for this PTSD treatment study at NYU Langone Health.
Additional Information
Why is this study being done?
"This study will investigate whether taking an estrogen pill in combination with
Prolonged Exposure (PE) therapy results in greater improvement of PTSD symptoms than PE alone. Participants receive PE therapy, a first-line psychotherapy for Post-traumatic Stress Disorder (PTSD).
Is this study for me?
You could be included in the study if you meet the following criteria.

Inclusion Criteria

  • Female, 18-45 years of age
  • Chronic (at least one-month post-trauma) PTSD symptoms
  • Stable medications for 3 or more months
  • Currently on oral contraceptives or vaginal birth control ring (e.g., Nuvaring) or transdermal birth control patch

Exclusion Criteria

  • Diagnosis of bipolar I disorder with a past year manic episode
  • Diagnosis of a psychotic disorder or psychotic symptoms
  • Diagnosis of moderate or severe substance use disorder
  • Cognitive impairment
  • History of neurological disease (that involves the brain), seizure, or significant head trauma
  • Significant suicidal ideation or self-harm
  • Concurrent trauma-focused psychotherapy
  • Pregnancy
  • Metallic implants or devices contraindicating magnetic resonance imaging
  • History of breast cancer or hormone-responsive cancer.
  • Use of benzodiazepines
What will happen if I participate in the study?
The first step is to complete this 30 minute phone interview during which we would ask you some questions about your mental and physical health history.  If eligible, we would invite you into our office for a full screening assessment, where we will determine your eligibility and explain the details of the study.

Once you are eligible and enrolled, you will complete 2 experimental days. The first day involves an electric shock to your foot that is for most people annoying but not painful. The purpose of the electric shock is to create a situation in which emotional learning may occur. You will receive no more than twelve of these electric shocks. This visit also includes a blood draw to measure the
level of estradiol in your body. On the second day, which takes place the day after the first
visit, you will return to our facilities and we will ask you to do a similar experiment as the first day but inside of our fMRI scanner. Following this 2-day visit, you will go through 6 Prolonged Exposure therapy sessions over 3 weeks: 2 sessions per week. After that, we will repeat the experimental visits over 2-days.
Will I be paid for being in this research study?
Compensation is provided for participation in this study.
Will it cost me anything to participate in this study?
There is no cost for you to participate in the study.