Hormonal Disorder
Research Study
The National Institutes of Health is studying if an FDA-approved medication can improve metabolic health in women diagnosed with Polycystic Ovary Syndrome.
The NIH Clinical Center, in Bethesda, MD
Compensation
Provided
taking oral birth control
Diagnosed With PCOS
18 - 40 Years Old
Fast Facts
About this research study:
Join a research study at the NIH investigating how an FDA-approved medication may be used to help your body regulate hormones better.
Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. The combination of metabolic, hormonal, and psychosocial conditions can lead to infertility, skin problems, depression, and insulin resistance.

This National Institutes of Health research study is examining how daily treatment with special medication (mirabegron) will affect hormone sensitivity in women with this condition. We hope that this medication can improve your overall metabolic health as well as improve conditions associated with PCOS, such as infertility and weight gain.
Additional Information
Why is this study being done?
The National Institutes of Diabetes and Digestive and Kidney Disorders research is being conducted to see if an existing FDA-approved medication can be used to help with Polycystic Ovary Syndrome. This study will examine if the daily treatment with this medication will improve insulin and hormone sensitivity in women.
Is this study for me?
You may qualify for this study if you meet the following criteria.

Eligibility Criteria:
  • Are a cisgender female
  • Are between the ages of 18 and 40 years old
  • Currently take oral contraceptives
What will happen if I participate in the study?
During the study you will:
  • Have a medical history and physical exam
  • Have 4 outpatient visits to include blood tests, EKG, and questionnaires
  • Have 4 separate inpatient visits at the NIH Clinical Center lasting 4 days each (over 3 months)
  • Have glucose tolerance tests, hyperinsulinemic tests, PET-CT scans, and liver ultrasounds
  • Take an FDA-approved medication and placebo tablet for 4-weeks each
Will I be paid for being in this research study?
Compensation is provided for participation in this study.
Will it cost me anything to participate in this study?
There is no cost for you to participate in our research program.