NIH PERSIST Study
COVID-19 Research
Join an NIH research study on the body's immune response to COVID-19 vaccines in individuals with and without immune deficiencies.
Participate from anywhere in the USA
Compensation Provided
Healthy OR Have an Immune Deficiency
Blood Sample
Collection
12 Years and Older
Fast Facts
About this research study:
The purpose of this study is to analyze the immune response to COVID-19 vaccination and outcomes in individuals with and without immune deficiencies.
Currently, people with immune disorders fall outside of guidance for the COVID-19 vaccination, as they are typically excluded from vaccine trials.

This study evaluates the immune response to COVID-19 vaccination and any vaccine-associated adverse events that may be experienced in individuals with different immune disorders.
Additional Information
Why is this study being done?
This study is investigating how your body's immune system will respond to COVID-19 vaccination. Researchers will be looking at all vaccine-associated dysregulations that may be experienced in individuals with different immune systems after receiving the vaccines.
Is this study for me?
Inclusion criteria:
  • You are age 12 or older
  • You do not have HIV
  • You are willing to provide blood samples
  • You are willing to allow the NIH to store your research samples
  • If female, you are not currently pregnant, breastfeeding, or trying to become pregnant
What will happen if I participate in the study?
Blood samples will be collected within 7 days before your first vaccination, and then 5 more times in the following two-year period.

Participants may also submit saliva samples every other week for 6 months to test for COVID-19 after vaccination.

The study can be completed remotely, and at-home finger stick blood collection kits and saliva sample kits can be mailed to you.

Individuals can still participate if they have started or completed vaccination; sampling will begin at the next relevant timepoint.
Will I be paid for being in this research study?
Compensation will be dependent on the sample collections and study visits that a subject participates in.
Will it cost me anything to participate in this study?
There is no cost for you to participate in the study.