Schizophrenia Research Studies
Yale University is partnering with individuals diagnosed with Schizophrenia to participate in a research study aimed at testing new therapeutic mechanisms for cognitive enhancement
Schizophrenia Research Studies
Yale University is partnering with individuals diagnosed with Schizophrenia to participate in a research study aimed at testing new therapeutic mechanisms for cognitive enhancement
Facts About Our Study
Our research study is studying the potential cognitive effects of CVL-562 in early-course schizophrenia, schizoaffective disorder or related psychotic disorder
Participants from 18 to 45 years old
Diagnosed with Schizophrenia, Schizoaffective, or Schizophreniform disorder within the last 10 years
Willing to participate in a study of the potential cognitive effects of a novel experimental medicine
Compensation up to $2,910 is provided
Our study is confidential
Our study is conducted at Yale University, New Haven, CT
Study Background
Schizophrenia is a disabling neuropsychiatric illness characterized by disturbances in perception of reality. The primary objective of this study is to examine the effects of novel medication on the neural signal of brain regions involved in cognition in patients with schizophrenia and related psychotic disorders.
Additional Information
Why is this study being done?
Schizophrenia affects approximately 1% of the population and is highly debilitating given the effects it has on cognition, sensory perception, and social/motivational functioning. Cognitive disturbances are considered to be one of the main reasons for enormous functional disability in patients with schizophrenia and associated psychotic illnesses. The overarching aim of this study is to further investigate areas of cognition impaired in schizophrenia, particularly spatial working memory as assessed with functional neuroimaging.
Is this study for me?
You may qualify for this study if you meet the following criteria.

Eligibility Criteria:
  • 18 to 45 years old
  • Diagnosed with Schizophrenia, Schizoaffective, or Schizophreniform disorder within the last 10 years
  • Willing to participate in a study of the potential cognitive effects of a novel experimental medicine
  • Able to do MRI scan
What will happen if I participate in this study?
Your participation in this study will require 7 total visits over approximately 2 months.

Study Treatment:
You will receive one of 5 various doses on each visit. 4 of these doses will be of the study drug,
and one will be a placebo, otherwise known as an inactive substance (such as a sugar pill). This is a double-blind study, meaning neither you nor the study doctor and staff will know to which of these groups you have been assigned to. However, in case of an emergency, the study doctor can get this information.

After Study Treatment:
You will be called approximately 1 month after this follow-up visit to assess for possible long-term effects (if any).
Will I be paid for being in this research study?
You will be paid up to a total of $2,910 if you complete this study.
Will it cost me anything to participate in this study?
There is no cost for you to participate in this study.